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Icenticaftor
CAS No. 1334546-77-8
Icenticaftor( QBW251 )
Catalog No. M28717 CAS No. 1334546-77-8
Icenticaftor is an orally active potentiator of CFTR channel.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 709 | In Stock |
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| 10MG | 972 | In Stock |
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| 25MG | 1467 | In Stock |
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| 50MG | 1962 | In Stock |
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| 100MG | 2673 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIcenticaftor
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NoteResearch use only, not for human use.
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Brief DescriptionIcenticaftor is an orally active potentiator of CFTR channel.
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DescriptionIcenticaftor is an orally active potentiator of CFTR channel.
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In VitroIcenticaftor (QBW251), an orally bioavailable small molecule CFTR potentiator, can restore CFTR function in specific CFTR genotypes as well as wild-type CFTR.
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In VivoIn Sprague-Dawley rats, the pharmacokinetic profile of Icenticaftor isestablished. After oral administration at a dose of 3 mg/kg, the oral bioavailability is 90%, and AUClast is 20?635 nmol/L?h.
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SynonymsQBW251
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PathwayApoptosis
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TargetCFTR
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RecptorHCV
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Research Area——
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Indication——
Chemical Information
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CAS Number1334546-77-8
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Formula Weight361.244
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Molecular FormulaC12H13F6N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 150 mg/mL (415.24 mM)
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SMILESCOc1nc(C(=O)NC[C@](C)(O)C(F)(F)F)c(N)cc1C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wahyuni, T.S., Widyawaruyanti, A., Lusida, M.I., et al.Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.Fitoterapia.99276-283(2014)
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