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PPQ-102
CAS No. 931706-15-9
PPQ-102( CFTR Inhibitor IV | Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV )
Catalog No. M16668 CAS No. 931706-15-9
PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 81 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 130 | In Stock |
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| 25MG | 269 | In Stock |
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| 50MG | 456 | In Stock |
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| 100MG | 730 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePPQ-102
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NoteResearch use only, not for human use.
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Brief DescriptionPPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
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DescriptionPPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
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In VitroCell Viability Assay Cell Line:E13.5 embryonic kidneys (embryonic kidney organ culture model of PKD)Concentration:0, 0.5, 5 μM Incubation Time:3 or 4 days Result:Remarkablyreduced the number and size of renal cysts formed in the 8-Br-cAMP-containing medium (showed ～60% inhibition of cyst formation at 0.5 μM, near complete absence of cysts at 2.5 and 5 μM).Remarkable reduced cyst size over 1 and 2 days in the 8-Br-cAMP-containing medium.
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In Vivo——
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SynonymsCFTR Inhibitor IV | Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
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PathwayApoptosis
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TargetCFTR
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RecptorCFTR
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number931706-15-9
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Formula Weight438.48
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Molecular FormulaC26H22N4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 5 mg/mL
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SMILESO=C1N(C)C(C(C(N1C)=O)=C2C3=CC=CC=C3)=C4N2C5=C(C=CC=C5)NC4C6=CC=C(C)O6
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Chemical Name7,9-dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tradtrantip L, et al. J Med Chem. 2009 Oct 22;52(20):6447-55.
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