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Nesolicaftor
CAS No. 1953130-87-4
Nesolicaftor( PTI-428 | Nesolicaftor )
Catalog No. M26798 CAS No. 1953130-87-4
PTI-428 specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 237 | In Stock |
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| 5MG | 215 | In Stock |
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| 10MG | 377 | In Stock |
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| 25MG | 651 | In Stock |
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| 50MG | 907 | In Stock |
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| 100MG | 1228 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNesolicaftor
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NoteResearch use only, not for human use.
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Brief DescriptionPTI-428 specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.
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DescriptionPTI-428 specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.
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In VitroNesolicaftor (PTI-428) (30 μM, 24 h) can increase CFTR function, such as causing a larger change in inh-172 in 16HBE14o-cells expressing G542X-CFTR, also can increase in F508del-CFTR function of CFBE41o-cells expressing F508del-CFTR in a dose-dependent manner.
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In Vivo——
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SynonymsPTI-428 | Nesolicaftor
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PathwayApoptosis
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TargetCFTR
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RecptorG-quadruplexe| Telomerase
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Research Area——
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Indication——
Chemical Information
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CAS Number1953130-87-4
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Formula Weight354.366
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Molecular FormulaC18H18N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (705.50 mM)
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SMILESC[C@@H](O)c1nnc(o1)[C@H]1C[C@@H](C1)NC(=O)c1cc(no1)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Fujimori J, et al. Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res. 2011 Nov;29(11):1707-11.
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