IOWH-032( iOWH-032 | IOWH032 | IOWH 032 )

Catalog No. M10658 CAS No. 1191252-49-9

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Product Name

IOWH-032
Note

Research use only, not for human use.
Brief Description

A novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.
Description

A novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.(In Vitro):IOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells.
In Vitro

IOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells. Western Blot Analysis Cell Line:CFBE41o- cells Concentration:10 μM Incubation Time:0, 24, 48, 72 h Result:Increased the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells in a time-dependent manner.
In Vivo

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Synonyms

iOWH-032 | IOWH032 | IOWH 032
Pathway

Apoptosis
Target

CFTR
Recptor

CFTR
Research Area

Other Indications
Indication

Other Disease

CAS Number

1191252-49-9
Formula Weight

545.1802
Molecular Formula

C22H15Br2N3O4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(C1=NC(C2=CC(Br)=C(O)C(Br)=C2)=NO1)NCC3=CC=C(OC4=CC=CC=C4)C=C3
Chemical Name

1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-

1. Cui G, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L192-207.

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