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IOWH-032
CAS No. 1191252-49-9
IOWH-032( iOWH-032 | IOWH032 | IOWH 032 )
Catalog No. M10658 CAS No. 1191252-49-9
A novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 49 | In Stock |
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| 25MG | 85 | In Stock |
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| 50MG | 131 | In Stock |
|
| 100MG | 205 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIOWH-032
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NoteResearch use only, not for human use.
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Brief DescriptionA novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.
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DescriptionA novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.(In Vitro):IOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells.
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In VitroIOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells. Western Blot Analysis Cell Line:CFBE41o- cells Concentration:10 μM Incubation Time:0, 24, 48, 72 h Result:Increased the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells in a time-dependent manner.
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In Vivo——
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SynonymsiOWH-032 | IOWH032 | IOWH 032
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PathwayApoptosis
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TargetCFTR
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RecptorCFTR
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1191252-49-9
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Formula Weight545.1802
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Molecular FormulaC22H15Br2N3O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C1=NC(C2=CC(Br)=C(O)C(Br)=C2)=NO1)NCC3=CC=C(OC4=CC=CC=C4)C=C3
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Chemical Name1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cui G, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L192-207.
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