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CFTR corrector 4

CAS No. 1918142-34-3

CFTR corrector 4( —— )

Catalog No. M32840 CAS No. 1918142-34-3

CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CFTR corrector 4
  • Note
    Research use only, not for human use.
  • Brief Description
    CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer.
  • Description
    CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis.
  • In Vitro
    CFTR corrector 4 possesses high potency and efficacy with a EC50 of 0.028 μM in this HBE-TECC assay that assess the CFTR function, this lead resides in undesirable drug-like space with high molecular weight, and high HPLC Log?D, indicating high lipophilicity. HBE-TECC: (Human?Bronchial?Epithelial-Trans-Epithelial?Current?Clamp) assay.CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with a EC50 value 130 nM in the cell surface expression (CSE-HRP) assay.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    CFTR
  • Recptor
    CFTR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1918142-34-3
  • Formula Weight
    539.52
  • Molecular Formula
    C29H27F2NO7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 110 mg/mL (203.88 mM; Ultrasonic )
  • SMILES
    COc1ccc2[C@@H](C[C@@H](Oc2c1)c1ccc(OC)c(OC)c1)NC(=O)C1(CC1)c1ccc2OC(F)(F)Oc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)?
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