Tienilic Acid

Research use only, not for human use.

Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity.

Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity.(In Vivo):In female and male Sprague-Dawley rats, Tienilic Acid decreased blood pressure and serum uric acid at 30 mg/kg. Tienilic acid decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg. Tienilic Acid significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly. Tienilic Acid also induced unicellular necrosis of small groups of liver cells.

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Tienilic acid (100 mg/lg in rats and mice, 5 mg/kg in pigs and dog; PO and IV; single dosage) is only found in plasma, eliminates by the biliary and the urinary fast, and exhibits small differences in the different species.Tienilic acid (0-480 mg/kg; PO; for 28 days) decreases blood pressure, serum, uric acidhemoglobin, and increased S-GPT; induces unicellular necrosis of small groups of liver cells. Animal Model:Rats, mice, pigs and dogs Dosage:100 mg/lg in rats and mice, 5 mg/kg in pigs and dogs Administration:PO and IV; single dosageResult:Only found in plasma with important bindings to the plasma proteins at the blood level; pharmacological action for several hours; eliminated by the biliary and particularly the urinary fast, practically total in the first 48 hours after administration; only small differences were observed for the parameters measured in the different species.Animal Model:Female and male Sprague-Dawley rats Dosage:0, 30, 120 and 480 mg/kg Administration:PO; for 28 days Result:Decreased blood pressure and serum uric acid at 30 mg/kg; decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg; significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly; besides, induced unicellular necrosis of small groups of liver cells.

Ticrynafen | ANP 3624

Metabolic Enzyme/Protease

P450

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40180-04-9

331.16

C13H8Cl2O4S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (301.96 mM)

OC(=O)COc1ccc(C(=O)c2cccs2)c(Cl)c1Cl

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(-20℃)

With Ice Pack

≥ 2 years