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Home - Products - Metabolic Enzyme/Protease - P450 - CYP1B1-IN-4

CYP1B1-IN-4

CAS No. 2685779-55-7

CYP1B1-IN-4( —— )

Catalog No. M36490 CAS No. 2685779-55-7

CYP1B1-IN-4, a 2,4-diarylthiazole compound, exhibits selective inhibition of CYP1B1 (IC50=0.2 nM), demonstrating minimal cytotoxicity and high stability in human and rat liver microsomes .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CYP1B1-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    CYP1B1-IN-4, a 2,4-diarylthiazole compound, exhibits selective inhibition of CYP1B1 (IC50=0.2 nM), demonstrating minimal cytotoxicity and high stability in human and rat liver microsomes .
  • Description
    CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    P450
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2685779-55-7
  • Formula Weight
    322.38
  • Molecular Formula
    C18H14N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (193.87 mM; Ultrasonic )
  • SMILES
    O(C)C1=C(C2=NC(=CS2)C3=CC=C(C#N)C=C3)C=CC(OC)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hachey AC, et al. Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach. J Med Chem. 2022 Dec 15. ?
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