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Licostinel
CAS No. 153504-81-5
Licostinel( ACEA-1021 | ACEA 1021 | ACEA1021 | CGP-63446 | CGP 63446 )
Catalog No. M27895 CAS No. 153504-81-5
Licostinel is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 83 | In Stock |
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| 25MG | 174 | In Stock |
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| 50MG | 276 | In Stock |
|
| 100MG | 412 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLicostinel
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NoteResearch use only, not for human use.
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Brief DescriptionLicostinel is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
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DescriptionLicostinel is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
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In Vitro——
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In VivoAnimal Model:The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice. The transient model of focal ischemia in Wistar and Sprague –Dawley rats.Dosage:5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h Administration:A single intravenous injection bolus continuous infusionResult:Decreased infarct size.Animal Model:Male Sprague-Dawley rats Dosage:20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins Administration:Intravenous injection (i.v.) bolus continuous infusionResult:Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner.
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SynonymsACEA-1021 | ACEA 1021 | ACEA1021 | CGP-63446 | CGP 63446
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PathwayNeuroscience
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TargetGluR
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RecptorNucleoside
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Research Area——
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Indication——
Chemical Information
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CAS Number153504-81-5
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Formula Weight276.03
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Molecular FormulaC8H3Cl2N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (45.28 mM)
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SMILES[O-][N+](=O)c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Taniguchi T, et al. Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis. Nat Chem Biol. 2018 Nov;14(11):1010-1020.
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