Cutamesine dihydrochloride
CAS No. 165377-44-6
Cutamesine dihydrochloride( SA4503 (dihydrochloride) | AGY94806 dihydrochloride )
Catalog No. M17359 CAS No. 165377-44-6
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 79 | In Stock |
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| 25MG | 170 | In Stock |
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| 50MG | 269 | In Stock |
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| 100MG | 415 | In Stock |
|
| 200MG | 600 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCutamesine dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM).
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DescriptionCutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. In a rat model of experimental stroke, it enhances brain plasticity and sensorimotor function.(In Vitro):The sigma receptor might be involved in several diseases in the central nervous system. Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC50=17.4 nM) than σ2 (IC50=1,784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (Ki=4.6 nM) over σ2 (Ki=63.1 nM) sites in guinea pig brain homogenates. Cutamesine protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2. Cutamesine reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1.(In Vivo):Cutamesine extends the survival time in the SOD1G93A mice.
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In VitroThe sigma receptor might be involved in several diseases in the central nervous system. Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC50=17.4 nM) than σ2 (IC50=1,784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (Ki=4.6 nM) over σ2 (Ki=63.1 nM) sites in guinea pig brain homogenates. Cutamesine protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2. Cutamesine reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1.
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In VivoCutamesine extends the survival time in the SOD1G93A mice.
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SynonymsSA4503 (dihydrochloride) | AGY94806 dihydrochloride
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PathwayNeuroscience
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TargetGluR
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Recptorσ1
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number165377-44-6
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Formula Weight441.43
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Molecular FormulaC23H32N2O2·2HCl
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Purity>98% (HPLC)
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SolubilityDMSO : 30 mg/mL 67.96 mM;
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SMILESCOc1c(cc(cc1)CCN1CCN(CC1)CCCc1ccccc1)OC.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tagashira H, et al. Biochim Biophys Acta. 2013, 1830(4):3082-94.
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