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VU0650786

CAS No. 1809085-30-0

VU0650786( —— )

Catalog No. M23823 CAS No. 1809085-30-0

VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 258 In Stock
5MG 235 In Stock
10MG 330 In Stock
25MG 560 In Stock
50MG 783 In Stock
100MG 1079 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    VU0650786
  • Note
    Research use only, not for human use.
  • Brief Description
    VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM).
  • Description
    VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.
  • In Vitro
    ——
  • In Vivo
    VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice.The pharmacokinetic parameters of VU0650786 (compound 106) in rats.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    mGluR3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1809085-30-0
  • Formula Weight
    387.8
  • Molecular Formula
    C18H15ClFN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 240 mg/mL (618.88 mM; Need ultrasonic);H2O: insoluble
  • SMILES
    ClC1=CN=C(OCC2=NN([C@H](C)CN(C3=C(F)N=CC=C3)C4=O)C4=C2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500.
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