MNI 137( —— )

Catalog No. M33891 CAS No. 946619-21-2

MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

MNI 137
Note

Research use only, not for human use.
Brief Description

MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.
Description

MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Neuroscience
Target

GluR
Recptor

GluR
Research Area

——
Indication

——

Chemical Information

CAS Number

946619-21-2
Formula Weight

341.16
Molecular Formula

C15H9BrN4O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (244.25 mM; Ultrasonic (<60°C)
SMILES

O=C1NC=2C(N=C(C1)C=3C=C(C#N)N=CC3)=CC=C(Br)C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Hemstapat K, et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007;322(1):254-264.?

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