Pregnenolone Carbonitrile

Research use only, not for human use.

Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.

Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.(In Vitro):Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults.(In Vivo):In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression.

——

Animal Model:WT and Pxr-/- mice Dosage:40 mg/kg Administration:IP; per day for two days Result:Induced the expression of Cyp3a11 and Cyp2b10 at the mRNA, protein, and enzymatic levels in WT mice.Had little effect on the expression of Cyp3a11 in Pxr-/- mice

5-Pregnen-3β-ol-20-one-16α-carbonitrile | Pregnenolone 16α-carbonitrile?

Metabolic Enzyme/Protease

P450

enoyl-acyl carrier protein reductase (FabI)|S. aureus

——

——

1434-54-4

341.49

C22H31NO2

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (58.57 mM)

C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](O)CC4)[H])[H])(C[C@@H](C#N)[C@@H]2C(C)=O)[H]

——

(-20℃)

With Ice Pack

≥ 2 years