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CYP4A11/CYP4F2-IN-1
CAS No. 502654-40-2
CYP4A11/CYP4F2-IN-1( —— )
Catalog No. M36462 CAS No. 502654-40-2
CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor, applicable for research on kidney, cardiovascular, and cerebrovascular diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 121 | In Stock |
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| 5MG | 202 | In Stock |
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| 10MG | 297 | In Stock |
|
| 25MG | 502 | In Stock |
|
| 50MG | 699 | In Stock |
|
| 100MG | 918 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1841 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCYP4A11/CYP4F2-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionCYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor, applicable for research on kidney, cardiovascular, and cerebrovascular diseases.
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DescriptionCYP4A11/CYP4F2-IN-1 is a potent dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 19 nM and 17 nM, respectively. CYP4A11/CYP4F2-IN-1 has potential for the research of renal diseases.
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In VitroCYP4A11/CYP4F2-IN-1 (compound 2) inhibits 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC50 of 4.2 nM.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetP450
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RecptorP450
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Research Area——
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Indication——
Chemical Information
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CAS Number502654-40-2
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Formula Weight285.36
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Molecular FormulaC15H15N3OS
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Purity>98% (HPLC)
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Solubility——
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SMILESN1=CSC(=C1C)CCOC=2C=CC(=CC2)C3=NNC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65(21):14599-14613. ?
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