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NCT-502

CAS No. 1542213-00-2

NCT-502( N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide )

Catalog No. M26771 CAS No. 1542213-00-2

NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 54 In Stock
2MG 31 In Stock
5MG 49 In Stock
10MG 75 In Stock
25MG 154 In Stock
50MG 235 In Stock
100MG 406 In Stock
200MG Get Quote In Stock
500MG 913 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NCT-502
  • Note
    Research use only, not for human use.
  • Brief Description
    NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.
  • Description
    NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.(In Vitro):NCT-502 is cytotoxic to MDA-MB-468 (EC50: 15.2 μM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    Crimean-Congo hemorrhagic fever virus (CCHFV)| Nucleoside Antimetabolite/Analog
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1542213-00-2
  • Formula Weight
    395.45
  • Molecular Formula
    C18H20F3N5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 130 mg/mL (328.74 mM)
  • SMILES
    Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccc(cn2)C(F)(F)F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.
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