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hDHODH-IN-5
CAS No. 2029049-77-0
hDHODH-IN-5( DHODH-IN-7 )
Catalog No. M26160 CAS No. 2029049-77-0
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 176 | In Stock |
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| 5MG | 161 | In Stock |
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| 10MG | 234 | In Stock |
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| 25MG | 376 | In Stock |
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| 50MG | 548 | In Stock |
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| 100MG | 780 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamehDHODH-IN-5
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NoteResearch use only, not for human use.
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Brief DescriptionhDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase.
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DescriptionhDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).(In Vitro):hDHODH-IN-5 induces differentiation in ER-HOX-GFP, THP1, and U937 human AML cell lines with EC50s of 3.6, 2.7, and 2.5 μM, respectively.
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In VitroThe lysozyme-GFPER-HoxA9 murine cell line (ER-HOX-GFP) and the THP1 and U937 human AML cell lines were cultured with compounds in a 4-day differentiation assay. DHODH-IN-7 shows EC50s of 3.6, 2.7, and 2.5 μM for ER-HOX-GFP, THP1 and U937 human AML cell lines, respectively.
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In Vivo——
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SynonymsDHODH-IN-7
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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Recptorp300
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Research Area——
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Indication——
Chemical Information
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CAS Number2029049-77-0
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Formula Weight390.406
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Molecular FormulaC21H21F3N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(F)(F)c1ccc(cc1)C(=O)NCCC(=O)N[C@@H]1CCCc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mantelingu K, et al. Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy. J Phys Chem B. 2007;111(17):4527-4534.
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