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PfDHODH-IN-2
CAS No. 425629-94-3
PfDHODH-IN-2( —— )
Catalog No. M22750 CAS No. 425629-94-3
PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 102 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 141 | In Stock |
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| 25MG | 259 | In Stock |
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| 50MG | 375 | In Stock |
|
| 100MG | 533 | In Stock |
|
| 200MG | 724 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePfDHODH-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionPfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor.
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DescriptionPfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of malaria.
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In VitroMalaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality.PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC50=1.113 μM) over hDHODH (IC50>50 μM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 values of both >20 μM, respectively in whole cell assays.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorPfDHODH
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Research Area——
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Indication——
Chemical Information
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CAS Number425629-94-3
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Formula Weight297.76
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Molecular FormulaC13H12ClNO3S
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Purity>98% (HPLC)
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SolubilityDMSO:12 mg/mL?(40.3 mM;?Need ultrasonic)
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SMILESCCOC(=O)C1=C(Nc2ccc(Cl)cc2)SCC1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24.
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