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BIP-135
CAS No. 941575-71-9
BIP-135( —— )
Catalog No. M26630 CAS No. 941575-71-9
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 74 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 221 | In Stock |
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| 50MG | 323 | In Stock |
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| 100MG | 462 | In Stock |
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| 200MG | 638 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBIP-135
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NoteResearch use only, not for human use.
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Brief DescriptionBIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.
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DescriptionBIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.(In Vitro):BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress. BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.(In Vivo):BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. And it does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).
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In VitroBIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress. Western Blot Analysis Cell Line:Human SMA fibroblasts Concentration:20 μM, 25 μM, 30 μM Incubation Time:72 hours Result:Led to a 7-fold increase in SMN levels at 25 μM.
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In VivoBIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. Animal Model:Male and female SMN2+/+, SMN2Δ7+/+, Smn+/– mice Dosage:75 mg/kg Administration:Intraperitoneal injection; daily; from postnatal day 0 to 21Result:Caused a modest extension in the median survival of SMA KO animals by two days.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number941575-71-9
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Formula Weight421.25
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Molecular FormulaC21H13BrN2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (148.37 mM)
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SMILESCn1cc(C2=C(C(=O)NC2=O)c2coc3ccccc23)c2cc(Br)ccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Au?ynait? A, et al. Identification of a 2'-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries. Molecules. 2018;23(11):2904. Published 2018 Nov 7.
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