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GSK3-IN-3
CAS No. 331963-27-0
GSK3-IN-3( —— )
Catalog No. M36514 CAS No. 331963-27-0
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 75 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 275 | In Stock |
|
| 50MG | 423 | In Stock |
|
| 100MG | 622 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGSK3-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionGSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.
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DescriptionGSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA.
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In VitroImmunofluorescenceCell Line:Parkin-expressing U2OS-iMLS cells Concentration:1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM, and 25 μM; Incubation Time:24 hour sResult:Induced a mitochondrial morphology change from a filament-shaped network to a more round-shaped network.Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:0.5 μM, 1 μM, 3 μM, 5 μM, and 10 μM Incubation Time:16 hours; with 35 μM 6-OHDA Result:Inhibited cell growth with an IC50 value of 2.57 μM.
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorMitophagy | GSK-3
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Research Area——
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Indication——
Chemical Information
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CAS Number331963-27-0
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Formula Weight429.55
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Molecular FormulaC24H35N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 4.17 mg/mL (9.71 mM; Ultrasonic (<60°C)
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SMILESC(C)N1C=2C(C(O)=C(C(NNC(CCCCCCCCCCC)=O)=O)C1=O)=CC=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Maestro I, et al. Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease. ACS Chem Neurosci. 2021 Dec 15;12(24):4512-4523. ?
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