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Cazpaullone
CAS No. 914088-64-5
Cazpaullone( 9-Cyano-1-azapaullone )
Catalog No. M16568 CAS No. 914088-64-5
Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCazpaullone
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NoteResearch use only, not for human use.
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Brief DescriptionCazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM.
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DescriptionCazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM); stimulates INS-1E beta cell replication and protects INS-1E cells against glucolipotoxicity induced cell death, also stimulates the replication of primary beta cells in isolated rat islets.
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In Vitro——
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In Vivo——
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Synonyms9-Cyano-1-azapaullone
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3
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Research Area——
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Indication——
Chemical Information
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CAS Number914088-64-5
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Formula Weight274.283
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Molecular FormulaC16H10N4O
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Purity>98% (HPLC)
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Solubility——
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SMILESN#CC1=CC2=C(NC3=C2CC(NC4=CC=CN=C43)=O)C=C1
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Chemical Name6-Oxo-5,6,7,12-tetrahydropyrido(3',2'-2,3)azepino(4,5-b)indole-9-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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BIP-135
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.
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GSK3-IN-2
GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.
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9-ING-41
9-ING-41 is a glycogen synthase kinase-3 inhibitor.9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2]. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1]. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM.
