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7-Chlorokynurenic acid
CAS No. 18000-24-3
7-Chlorokynurenic acid( 7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline )
Catalog No. M26039 CAS No. 18000-24-3
7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 64 | In Stock |
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| 5MG | 36 | In Stock |
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| 10MG | 58 | In Stock |
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| 25MG | 122 | In Stock |
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| 50MG | 222 | In Stock |
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| 100MG | 400 | In Stock |
|
| 200MG | 579 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name7-Chlorokynurenic acid
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NoteResearch use only, not for human use.
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Brief Description7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site.
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Description7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.(In Vivo):In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response.
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In Vitro——
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In VivoMale Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
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Synonyms7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline
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PathwayNeuroscience
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TargetGluR
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number18000-24-3
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Formula Weight223.61
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Molecular FormulaC10H6ClNO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 16.67 mg/mL (74.55 mM)
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SMILESO=C(O)C=1N=C2C=C(Cl)C=CC2=C(O)C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Cutamesine dihydroch...
Cutamesine dihydrochloride is a selective?σ1 receptor agonist (IC50: 17.4 nM).
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
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SIB-1757
SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM),SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?
