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SIB-1757

CAS No. 31993-01-8

SIB-1757( 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 )

Catalog No. M21962 CAS No. 31993-01-8

SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM),SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 52 In Stock
2MG 30 In Stock
5MG 48 In Stock
10MG 77 In Stock
25MG 140 In Stock
50MG 217 In Stock
100MG 306 In Stock
200MG 455 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    SIB-1757
  • Note
    Research use only, not for human use.
  • Brief Description
    SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM),SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.
  • Description
    SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM).SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection. In SNL rats, i.th. SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude; SIB-1757 was inactive against allodynia when given systemically. SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw; administration to the contralateral paw had no effect. SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    6-methyl-2-[(E)-phenyldiazenyl]pyridin-3
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    mGluR5
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    31993-01-8
  • Formula Weight
    213.24
  • Molecular Formula
    C12H11N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:17 mg/ml(79.72 mM)
  • SMILES
    Cc1ccc(O)c(n1)\N=N\c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dogrul A , Ossipov M H , Lai J , et al. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats[J]. 2000, 292(2):0-118.2. Varney M A A , Cosford N D P , Jachec C , et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5[J]. Journal of Pharmacology & Experimental Therapeutics, 1999, 290(1):170-181.
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