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lavendustin B
CAS No. 125697-91-8
lavendustin B( Lavendustin B )
Catalog No. M17227 CAS No. 125697-91-8
Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 71 | In Stock |
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| 5MG | 110 | In Stock |
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| 10MG | 178 | In Stock |
|
| 25MG | 403 | In Stock |
|
| 50MG | 592 | In Stock |
|
| 100MG | 844 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Namelavendustin B
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NoteResearch use only, not for human use.
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Brief DescriptionLavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).
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DescriptionLavendustin B is a Tyrosine Kinase Inhibitor amd an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).
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In VitroIn HL-60 cells, Lavendustin B (0-1000 μM) inhibits the uptake of methylglucose, deoxyglucose, and dehydroascorbic acid in human erythrocytes in a dose-dependent manner, with 50% inhibition observed at approximately 10-30 μM. Moreover, increasing concentrations of Lavendustin B inhibited, in a dose-dependent manner, the binding of cytochalasin B to human erythrocyte membranes.
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In Vivo——
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SynonymsLavendustin B
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PathwayNeuroscience
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TargetGluR
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RecptorTyrosine Kinase inhibitor| HIV-1 integrase
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Research Area——
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Indication——
Chemical Information
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CAS Number125697-91-8
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Formula Weight365.39
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Molecular FormulaC21H19NO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (136.84 mM)
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SMILESO=C(O)c1cc(N(Cc2ccccc2O)Cc2ccccc2O)ccc1O
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Chemical Name5-[Bis[(2-hydroxyphenyl)methyl]amino]-2-hydroxy-benzoic Acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Agharbaoui FE, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-83
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