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AMN082
CAS No. 83027-13-8
AMN082( —— )
Catalog No. M24820 CAS No. 83027-13-8
AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 130 | In Stock |
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| 50MG | 207 | In Stock |
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| 100MG | 333 | In Stock |
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| 200MG | 466 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMN082
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NoteResearch use only, not for human use.
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Brief DescriptionAMN082 is a metabotropic glutamate receptor 7 allosteric agonist.
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DescriptionAMN082 is a metabotropic glutamate receptor 7 allosteric agonist.
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In VitroPreincubation of the synaptosomes with AMN082 (1 μM) for 10 min before 4-aminopyridine treatment efficiently inhibits the 4-aminopyridine-evoked release of glutamate, without altering the basal release of glutamate.
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In VivoAMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7+/+ mice (C57BL/6 genetic background).AMN082 (1.25-5.0 mg/kg, i.p.; 30 min before every Cocaine injection during repeated drug administration or before Cocaine challenge) dose-dependently attenuates the development, as well as the expression of Cocaine locomotor sensitization.
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptormGluR7
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Research Area——
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Indication——
Chemical Information
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CAS Number83027-13-8
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Formula Weight392.54
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Molecular FormulaC28H28N2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (31.84 mM)
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SMILESC(CNC(c1ccccc1)c1ccccc1)NC(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Marszalek, M, Komsta, et al. AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice[J]. Progress in Neuro Psychopharmacology & Biological Psychiatry An International Research Review & News Journal, 2015.
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