AMN082

Research use only, not for human use.

AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.

AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.

Preincubation of the synaptosomes with AMN082 (1 μM) for 10 min before 4-aminopyridine treatment efficiently inhibits the 4-aminopyridine-evoked release of glutamate, without altering the basal release of glutamate.

AMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7+/+ mice (C57BL/6 genetic background).AMN082 (1.25-5.0 mg/kg, i.p.; 30 min before every Cocaine injection during repeated drug administration or before Cocaine challenge) dose-dependently attenuates the development, as well as the expression of Cocaine locomotor sensitization.

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Neuroscience

GluR

mGluR7

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83027-13-8

392.54

C28H28N2

>98% (HPLC)

In Vitro:?DMSO : 12.5 mg/mL (31.84 mM)

C(CNC(c1ccccc1)c1ccccc1)NC(c1ccccc1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years