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GET73
CAS No. 202402-01-5
GET73( Gamma hydroxybutyric acid analogue | GET 73 )
Catalog No. M23905 CAS No. 202402-01-5
GET73 is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 5MG | 33 | In Stock |
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| 10MG | 51 | In Stock |
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| 25MG | 106 | In Stock |
|
| 50MG | 157 | In Stock |
|
| 100MG | 237 | In Stock |
|
| 200MG | 352 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGET73
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NoteResearch use only, not for human use.
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Brief DescriptionGET73 is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.
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DescriptionGET73 is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.
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In VitroGET73 (1 μM, 10 μM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production. Cell Viability Assay Cell Line:Rat hippocampal neurons Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:1 hour Result:Prevented the ethanol (75 mM, 4 days) -induced MTT reduction.
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In VivoGET73 (5–50?mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test. Animal Model:Male SD rats (200-300?g and 300–350?g)Dosage:5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg Administration:Oral gavage Result:Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test.
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SynonymsGamma hydroxybutyric acid analogue | GET 73
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PathwayNeuroscience
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TargetGluR
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RecptormGluR5
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Research Area——
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Indication——
Chemical Information
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CAS Number202402-01-5
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Formula Weight275.27
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Molecular FormulaC13H16F3NO2
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Purity>98% (HPLC)
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SolubilityDMSO:97 mg/mL?(352.38 mM;?Need ultrasonic)
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SMILESCOCCCC(NCc1ccc(C(F)(F)F)cc1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35.
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