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PF-4878691
CAS No. 532959-63-0
PF-4878691( 3M-852A )
Catalog No. M24509 CAS No. 532959-63-0
PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 154 | In Stock |
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| 5MG | 140 | In Stock |
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| 10MG | 235 | In Stock |
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| 25MG | 511 | In Stock |
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| 50MG | 830 | In Stock |
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| 100MG | 1349 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-4878691
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NoteResearch use only, not for human use.
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Brief DescriptionPF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
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DescriptionPF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
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In Vitro——
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In VivoAnimal Model:BALB/c mice , C57bl/6 J mice Dosage:30 mg/kg, 60 mg/kg, 90 mg/kg, 150 mg/kg Administration:Oral gavage (p.o.)Result:Induced dose and time dependant lymphopenia and 2,5,oligoadenylate synthetase (2,5,OAS).Caused cardiovascular changes. Significantly increased TLR7 receptor RNA.
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Synonyms3M-852A
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR7
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Research Area——
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Indication——
Chemical Information
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CAS Number532959-63-0
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Formula Weight361.46
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Molecular FormulaC17H23N5O2S
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Purity>98% (HPLC)
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SolubilityDMSO:19.23 mg/mL (53.20 mM; Need ultrasonic)
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SMILESCCc1nc(c(N)nc2ccccc22)c2n1CCCCNS(C)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.
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