AXC-715 trihydrochloride
CAS No. 2479276-17-8
AXC-715 trihydrochloride( —— )
Catalog No. M36450 CAS No. 2479276-17-8
AXC-715 trihydrochloride (T785 trihydrochloride) is a TLR7/TLR8 dual agonist for the synthesis of antibody-adjuvanted immunocouplings.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 208 | In Stock |
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| 10MG | 341 | In Stock |
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| 25MG | 554 | In Stock |
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| 50MG | 749 | In Stock |
|
| 100MG | 1004 | In Stock |
|
| 200MG | 1358 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAXC-715 trihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAXC-715 trihydrochloride (T785 trihydrochloride) is a TLR7/TLR8 dual agonist for the synthesis of antibody-adjuvanted immunocouplings.
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DescriptionAXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1. AXC-715 trihydrochloride, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR
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Research Area——
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Indication——
Chemical Information
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CAS Number2479276-17-8
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Formula Weight420.81
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Molecular FormulaC18H28Cl3N5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (297.05 mM; Ultrasonic )
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SMILESNC1=NC2=C(C=CC=C2)C3=C1N=C(CCCC)N3CCCCN.Cl.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Poly(I:C)
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CEP-40783
CEP-40783 is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).
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CU-CPT9b
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8;?Kd = 21 nM).?It inhibits activation of NF-?B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
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