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TLR4-IN-C34
CAS No. 40592-88-9
TLR4-IN-C34( —— )
Catalog No. M21768 CAS No. 40592-88-9
TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 65 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 126 | In Stock |
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| 50MG | 200 | In Stock |
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| 100MG | 296 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTLR4-IN-C34
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NoteResearch use only, not for human use.
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Brief DescriptionTLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
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DescriptionTLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
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In Vitro——
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In VivoTLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa. Animal Model:Experimental NEC induced in 7-8 day old mice.Dosage:1 mg/kg.Administration:Orally every morning.Result:Attenuated intestinal inflammation.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number40592-88-9
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Formula Weight389.4
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Molecular FormulaC??H??NO?
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Purity>98% (HPLC)
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SolubilityDMSO : 250 mg/mL (642.01 mM; Need ultrasonic)
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SMILESO=C(N[C@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)[C@H]1OC(C)C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779.
2. Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.
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