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Loxoribine
CAS No. 121288-39-9
Loxoribine( 7-Allyl-8-oxoguanosine,RWJ 21757 )
Catalog No. M22620 CAS No. 121288-39-9
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 33 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 49 | In Stock |
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| 25MG | 80 | In Stock |
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| 50MG | 114 | In Stock |
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| 100MG | 169 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLoxoribine
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NoteResearch use only, not for human use.
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Brief DescriptionLoxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
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DescriptionLoxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway. Loxoribine causes maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54, and CCR7. In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells.
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In VitroLoxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability.Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway.
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In VivoLoxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo. Animal Model:8-12 weeks male CBA/J mice Dosage:2 mg Administration:Subcutaneous or intravenous injection Result:activates murine natural killer (NK) cells in vivo.
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Synonyms7-Allyl-8-oxoguanosine,RWJ 21757
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR7
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Research Area——
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Indication——
Chemical Information
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CAS Number121288-39-9
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Formula Weight339.3
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Molecular FormulaC13H17N5O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (294.72 mM)
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SMILESNc1nc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(=O)n(CC=C)c2c(=O)[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97.
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