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A-317491
CAS No. 475205-49-3
A-317491( ABT 202 )
Catalog No. M24424 CAS No. 475205-49-3
A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 76 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 188 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA-317491
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NoteResearch use only, not for human use.
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Brief DescriptionA-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
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DescriptionA-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
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In Vitro——
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In VivoAnimal Model:Male adult Sprague-Dawley rats received an intraplantar injection of Freund's complete adjuvant Dosage:0.1, 1, 3, 10, 30 mg/kg Administration:A single s.c.Result:Produced a dose-dependent reduction in mechanical hyperalgesia 1 h, 3 h and 5 h post-administration.
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SynonymsABT 202
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PathwayNeuroscience
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TargetP2 Receptor
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RecptorHuman P2X3|P2X2|P2X3
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Research Area——
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Indication——
Chemical Information
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CAS Number475205-49-3
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Formula Weight565.57
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Molecular FormulaC33H27NO8
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Purity>98% (HPLC)
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SolubilityDMSO : 47 mg/mL (83.10 mM); H2O : < 0.1 mg/mL (insoluble)
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SMILESO=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jarvis MF,et al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84.
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