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IACS-13909
CAS No. 2160546-07-4
IACS-13909( BBP-398 | IACS 13909 )
Catalog No. M23977 CAS No. 2160546-07-4
IACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 215 | In Stock |
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| 10MG | 340 | In Stock |
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| 25MG | 575 | In Stock |
|
| 50MG | 822 | In Stock |
|
| 100MG | 1107 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIACS-13909
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NoteResearch use only, not for human use.
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Brief DescriptionIACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
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DescriptionIACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
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In VitroCell Proliferation Assay Cell Line:Wild-type SHP2 and KYSE-520 cells Concentration:10 nM, 100 nM, 1 μM, 10 μM Incubation Time:14 days Result:Potently suppressed the cell proliferation. Western Blot Analysis Cell Line:Wild-type SHP2 and KYSE-520 cellsConcentration:1 μM, 5 μM Incubation Time:2 hours Result:Potently suppressed pERK and pMEK levels.
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In VivoAnimal Model:NSG mice (20-28 g) injected with KYSE-520 cells Dosage:70 mg/kg Administration:Oral administration; daily; for 21 days Result:Potently suppressed tumor growth in mice.
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SynonymsBBP-398 | IACS 13909
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorSHP-2
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Research Area——
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Indication——
Chemical Information
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CAS Number2160546-07-4
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Formula Weight377.27
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Molecular FormulaC17H18Cl2N6
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Purity>98% (HPLC)
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SolubilityDMSO:9 mg/mL?(23.86 mM;?Need ultrasonic)
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SMILESNC1(C)CCN(C2=CN=C3C(NN=C3C4=CC=CC(Cl)=C4Cl)=N2)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Benzylideneacetone
Benzylideneacetone, a monoterpene produced by the insect pathogenic bacterium Xenorhabdus nematophila, is a phospholipase A2 (PLA2) inhibitor with inhibitory effects on arachidonoid biosynthesis and enhances baculovirus pathogenicity of Xylaria minor.
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Melittin TFA(20449-7...
Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.Melittin, an immunologically related PLA2 stimulating peptide from bee venom, increases the activity of the high molecular weight enzyme.
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Bromoenol lactone
Bromoenol lactone ((6E)-Bromoenol lactone) is a selective calcium-dependent phospholipase A2?(iPLA2β) and serine protease inhibitor that attenuates nicotine-induced breast cancer cell proliferation and migrations.
