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Home - Products - Metabolic Enzyme/Protease - Phospholipase - U 73343

U 73343

CAS No. 142878-12-4

U 73343( —— )

Catalog No. M23589 CAS No. 142878-12-4

U 73343 is an inactive analog of U 73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 60 In Stock
2MG 36 In Stock
5MG 58 In Stock
10MG 92 In Stock
25MG 187 In Stock
50MG 309 In Stock
100MG Get Quote In Stock
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Biological Information

  • Product Name
    U 73343
  • Note
    Research use only, not for human use.
  • Brief Description
    U 73343 is an inactive analog of U 73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant.
  • Description
    U 73343 is an inactive analog of U 73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
  • In Vitro
    U73343, which potently inhibits acid secretion, shows no inhibitory effect on either K+-pNPPase or H+,K+-ATPase activity. U73343 dose-dependently inhibits, histamine (Hist)-, carbachol (CCh)-, and dbcAMPstimulated aminopyrine accumulation in gastric glands.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phospholipase
  • Recptor
    PLC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    142878-12-4
  • Formula Weight
    466.66
  • Molecular Formula
    C29H42N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:5 mg/mL (10.71 mM; Need ultrasonic)
  • SMILES
    O=C(CC1)N(CCCCCCN[C@H]2CC[C@@]3([H])[C@]4([H])CCC5=CC(OC)=CC=C5[C@@]4([H])CC[C@]23C)C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Muto Y, et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997 Sep;282(3):1379-88.
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