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VU 0364739 hydrochloride
CAS No. 1244640-48-9
VU 0364739 hydrochloride( —— )
Catalog No. M33946 CAS No. 1244640-48-9
VU 0364739 hydrochloride (VU 0364739 HCl) is a selective and potent inhibitor of phospholipase D2 (PLD2) with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 255 | Get Quote |
|
| 5MG | 401 | Get Quote |
|
| 10MG | 643 | Get Quote |
|
| 25MG | 908 | Get Quote |
|
| 50MG | 1270 | Get Quote |
|
| 100MG | 1692 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVU 0364739 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionVU 0364739 hydrochloride (VU 0364739 HCl) is a selective and potent inhibitor of phospholipase D2 (PLD2) with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively.
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DescriptionVU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research.
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In VitroCell Proliferation Assay Cell Line:MDA-MB-231 cell line Concentration:10 μM Incubation Time:24 hours Result:Inhibited cell proliferation of MDA-MB-231 cells.Apoptosis Analysis Cell Line:MDA-MB-231 cell line Concentration:1, 10 and 100 μM Incubation Time:48 hours Result:Induced cell apoptosis at a dose of 10 μM under serum-free condition or 10% FBS containg condition.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorPhospholipase | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1244640-48-9
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Formula Weight482.98
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Molecular FormulaC26H28ClFN4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.O=C(NCCN1CCC2(C(=O)NCN2C=3C=CC=C(F)C3)CC1)C=4C=CC=5C=CC=CC5C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lavieri RR, et al. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19.?
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