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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - GSK620

GSK620

CAS No. 2088410-46-0

GSK620( —— )

Catalog No. M23936 CAS No. 2088410-46-0

GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 80 In Stock
2MG 29 In Stock
5MG 42 In Stock
10MG 67 In Stock
25MG 139 In Stock
50MG 219 In Stock
100MG 324 In Stock
200MG 483 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GSK620
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.
  • Description
    GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    pan-BD2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2088410-46-0
  • Formula Weight
    325.4
  • Molecular Formula
    C18H19N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (192.09 mM; Need ultrasonic)
  • SMILES
    CNC(=O)C1=CC(=CN(C1=O)CC2=CC=CC=C2)C(=O)NC3CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Seal JT, et al. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. J Med Chem. 2020;63(17):9093-9126.
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