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BMS-986242
CAS No. 1923844-48-7
BMS-986242( BMS986242 | BMS 986242 )
Catalog No. M23875 CAS No. 1923844-48-7
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 335 | In Stock |
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| 10MG | 500 | In Stock |
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| 25MG | 806 | In Stock |
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| 50MG | 1098 | In Stock |
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| 100MG | 1485 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBMS-986242
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
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DescriptionBMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
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In VitroBMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ～20 % max inhibition).
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In VivoBMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses. Animal Model:nu/nu MouseDosage:3~30 mg/kg Administration:P.o.Result:Exhibited dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses.
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SynonymsBMS986242 | BMS 986242
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PathwayMetabolic Enzyme/Protease
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TargetIDO
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RecptorIDO1
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Research Area——
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Indication——
Chemical Information
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CAS Number1923844-48-7
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Formula Weight410.91
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Molecular FormulaC24H24ClFN2O
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (608.41 mM; Need ultrasonic)
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SMILESO=C(N[C@@H]([C@H]1CC[C@@H](C2=CC=NC3=CC=C(F)C=C23)CC1)C)C4=CC=C(Cl)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cherney EC, et al. Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1. ACS Med Chem Lett. 2021;12(2):288-294. Published 2021 Jan 28.
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