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A-3 hydrochloride
CAS No. 78957-85-4
A-3 hydrochloride( —— )
Catalog No. M22434 CAS No. 78957-85-4
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 87 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 164 | In Stock |
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| 50MG | 269 | In Stock |
|
| 100MG | 431 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 918 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA-3 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).
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DescriptionA-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM, and it is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.
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In VitroA-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCK1|CK2|PKC|PKA
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Research Area——
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Indication——
Chemical Information
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CAS Number78957-85-4
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Formula Weight321.22
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Molecular FormulaC12H14Cl2N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (389.14 mM; Need ultrasonic)
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SMILESCl.NCCNS(=O)(=O)c1cccc2c(Cl)cccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol.?1986 Jun;29(6):577-81.
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