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(R)-DRF053 dihydrochloride
CAS No. 1241675-76-2
(R)-DRF053 dihydrochloride( DRF 053 | DRF053 )
Catalog No. M10975 CAS No. 1241675-76-2
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name(R)-DRF053 dihydrochloride
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NoteResearch use only, not for human use.
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Brief Description(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively.
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Description(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively; exhibits antiproliferative activity against human neuroblastoma SH-SY5Y cells with EC50 of 17.2 uM, prevents the CK1-dependent production of amyloid-beta in a cell model; specifically increases the number of duct-derived β-cells without affecting their proliferation.
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In Vitro——
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In Vivo——
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SynonymsDRF 053 | DRF053
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCasein Kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number1241675-76-2
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Formula Weight490.433
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Molecular FormulaC23H29Cl2N7O
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Purity>98% (HPLC)
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Solubility——
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SMILESCCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC=CC(=C3)C4=CC=CC=N4.Cl.Cl
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Chemical Name(R)-2-((9-isopropyl-6-((3-(pyridin-2-yl)phenyl)amino)-9H-purin-2-yl)amino)butan-1-ol dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Oumata N, et al. J Med Chem. 2008 Sep 11;51(17):5229-42.
2. Zelenak C, et al. Cell Physiol Biochem. 2012;29(1-2):171-80.
3.?Liu KC, et al. Diabetes. 2018 Jan;67(1):58-70.
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