CZEN-002

Research use only, not for human use.

CZEN-002 is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

CZEN-002 is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.(In Vitro):α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus.(In Vivo):α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions.

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Animal Model:IL-10–deficient mice Dosage:50 μg/0.2 ml saline Administration:I.p.Result:Given systemically effectively modulated inflammatory reactions.

α-Melanocyte-Stimulating Hormone (MSH) amide

Metabolic Enzyme/Protease

Adenylate Cyclase

Adenylyl cyclase

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581-05-5

1664.88

C77H109N21O19S

>98% (HPLC)

H2O:50 mg/mL (30.03 mM; Need ultrasonic)

OC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2cncn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc5cnc4ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@H](C(N)=O)C(C)C

(4S7S10S13S16S22S)-7-((1H-imidazol-4-yl)methyl)-16-((1H-indol-3-yl)methyl)-26-amino-22-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-10-benzyl-13-(3-guanidinopropyl)-4-((2S5S8S11S)-8-(4-hydroxybenzyl)-511-bis(hydroxymethyl)-2-(2-(methylthio)ethyl)-471013-tetraoxo-36912-tetraazatetradecanamido)-5811141720-hexaoxo-6912151821-hexaazahexacosanoic acid

(-20℃)

With Ice Pack

≥ 2 years