Cart
sales@molnova.com
4'-Methoxychalcone
CAS No. 959-23-9
4'-Methoxychalcone( —— )
Catalog No. M20874 CAS No. 959-23-9
4'-Methoxychalcone with a variety of pharmacological activities such as anti-tumor and anti-inflammatory activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 35 | In Stock |
|
| 50MG | 65 | In Stock |
|
| 100MG | 102 | In Stock |
|
| 200MG | 151 | In Stock |
|
| 500MG | 255 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Name4'-Methoxychalcone
-
NoteResearch use only, not for human use.
-
Brief Description4'-Methoxychalcone with a variety of pharmacological activities such as anti-tumor and anti-inflammatory activities.
-
Description4'-Methoxychalcone with a variety of pharmacological activities such as anti-tumor and anti-inflammatory activities.
-
In Vitro4'-Methoxychalcone (5 μM; 8 days) markedly increasesthe mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2,FAS,adiponectin and GluT 4.4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells.4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected. RT-PCR Cell Line:Preadipocyte 3T3-L1 cells Concentration:5 μM Incubation Time:0 day; 2 days; 4 days; 6 days; 8 days Result:Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte.Western Blot Analysis Cell Line:Preadipocyte 3T3-L1 cells Concentration:5 μM Incubation Time:8 days Result:Increased PPARγ expression in adipocyte.
-
In Vivo——
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetPPAR
-
RecptorPPARγ
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number959-23-9
-
Formula Weight238.28
-
Molecular FormulaC16H14O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:48mg/mL(201.44mM)
-
SMILESCOc1ccc(C(=O)C=Cc2ccccc2)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Younho Han Sung et al. Regulatory effects of 4-methoxychalcone on adipocyte differentiation through PPARγ activation and reverse effect on TNF-α in 3T3-L1 cells[J]. Food and Chemical Toxicology 2017.
molnova catalog
related products
-
Ciprofibrate
Ciprofibrate is a peroxisome proliferator-activated receptor agonist.
-
GW 6471
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist.
-
GSK376501A
GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.
