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LY518674
CAS No. 425671-29-0
LY518674( LY-674 )
Catalog No. M24391 CAS No. 425671-29-0
LY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 397 | In Stock |
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| 5MG | 359 | In Stock |
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| 10MG | 534 | In Stock |
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| 25MG | 847 | In Stock |
|
| 50MG | 1135 | In Stock |
|
| 100MG | 1535 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY518674
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NoteResearch use only, not for human use.
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Brief DescriptionLY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.
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DescriptionLY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα antagonist (EC50: 42 nM for human PPARα).
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In Vitro——
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In VivoLY518674 reduces triglycerides and increased HDL-C in vivo.LY518674 substantially increases apolipoprotein A-I (apoA-I) turnover without major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) .
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SynonymsLY-674
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorPPARα
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Research Area——
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Indication——
Chemical Information
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CAS Number425671-29-0
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Formula Weight409.48
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Molecular FormulaC23H27N3O4
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (610.53 mM; Need ultrasonic)
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SMILESCC(C)(C(O)=O)Oc1ccc(CCCC(N2)=NN(Cc3ccc(C)cc3)C2=O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bravo Y, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72.
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