IVA-337( Lanifibranor | IVA337 )

Catalog No. M16646 CAS No. 927961-18-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

IVA-337
Note

Research use only, not for human use.
Brief Description

IVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively.
Description

IVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively; reduces skin fibrosis in the mouse, and suppresses inflammation in vivo.Steatohepatitis,Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

Lanifibranor | IVA337
Pathway

Metabolic Enzyme/Protease
Target

PPAR
Recptor

PPAR
Research Area

Other Indications
Indication

Steatohepatitis

CAS Number

927961-18-0
Formula Weight

434.909
Molecular Formula

C19H15ClN2O4S2
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL 229.93 mM
SMILES

O=C(O)CCCC(N1S(=O)(C2=CC=C3N=CSC3=C2)=O)=CC4=C1C=CC(Cl)=C4
Chemical Name

4-(1-(1,3-Benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl)butanoic acid

1. Ruzehaji N, et al. Ann Rheum Dis. 2016 Dec;75(12):2175-2183. 2. Avouac J, et al. Ann Rheum Dis. 2017 Aug 11. pii: annrheumdis-2016-210821.

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