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Home - Products - Metabolic Enzyme/Protease - Retinoid Receptor - AM580

AM580

CAS No. 102121-60-8

AM580( CD336 | NSC608001 | Ro 40-6055 )

Catalog No. M20509 CAS No. 102121-60-8

AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM ).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 55 In Stock
2MG 31 In Stock
5MG 49 In Stock
10MG 75 In Stock
25MG 159 In Stock
50MG 310 In Stock
100MG 458 In Stock
200MG Get Quote In Stock
500MG 1042 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AM580
  • Note
    Research use only, not for human use.
  • Brief Description
    AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM ).
  • Description
    AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
  • In Vitro
    AM580 (GMP) (0.05 μM) induces mouse embryonic fibroblasts (MEFs) convert into chemically induced pluripotent stem cells (CiPSCs) with the adding in stage I and stage II medium.AM580 (GMP) (0-10 μM; 4 d) induces SH-SY5Y cells develop into neuron-like cells.AM580 (GMP) shows powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.AM580 (GMP) (2.5 μM; 4 d) induces myeloid progenitors develop into neutrophils.
  • In Vivo
    ——
  • Synonyms
    CD336 | NSC608001 | Ro 40-6055
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Retinoid Receptor
  • Recptor
    RARα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    102121-60-8
  • Formula Weight
    351.44
  • Molecular Formula
    C22H25NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:45 mg/mL (128.04 mM)
  • SMILES
    CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
  • Chemical Name
    4-(5588-tetramethyl-5678-tetrahydronaphthalene-2-carboxamido)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cheng Y H Utsunomiya H Pavone M E et al. Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms[J]. Journal of Molecular Endocrinology 2011 46(2):139-153.
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