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AM580
CAS No. 102121-60-8
AM580( CD336 | NSC608001 | Ro 40-6055 )
Catalog No. M20509 CAS No. 102121-60-8
AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 2MG | 31 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 75 | In Stock |
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| 25MG | 159 | In Stock |
|
| 50MG | 310 | In Stock |
|
| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1042 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAM580
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NoteResearch use only, not for human use.
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Brief DescriptionAM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM ).
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DescriptionAM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
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In VitroAM580 (GMP) (0.05 μM) induces mouse embryonic fibroblasts (MEFs) convert into chemically induced pluripotent stem cells (CiPSCs) with the adding in stage I and stage II medium.AM580 (GMP) (0-10 μM; 4 d) induces SH-SY5Y cells develop into neuron-like cells.AM580 (GMP) shows powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.AM580 (GMP) (2.5 μM; 4 d) induces myeloid progenitors develop into neutrophils.
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In Vivo——
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SynonymsCD336 | NSC608001 | Ro 40-6055
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PathwayMetabolic Enzyme/Protease
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TargetRetinoid Receptor
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RecptorRARα
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Research Area——
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Indication——
Chemical Information
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CAS Number102121-60-8
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Formula Weight351.44
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Molecular FormulaC22H25NO3
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Purity>98% (HPLC)
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SolubilityDMSO:45 mg/mL (128.04 mM)
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SMILESCC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
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Chemical Name4-(5588-tetramethyl-5678-tetrahydronaphthalene-2-carboxamido)benzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cheng Y H Utsunomiya H Pavone M E et al. Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms[J]. Journal of Molecular Endocrinology 2011 46(2):139-153.
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