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CAFESTOL
CAS No. 469-83-0
CAFESTOL( —— )
Catalog No. M20445 CAS No. 469-83-0
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 73 | In Stock |
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| 10MG | 125 | In Stock |
|
| 25MG | 214 | In Stock |
|
| 50MG | 342 | In Stock |
|
| 100MG | 514 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCAFESTOL
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NoteResearch use only, not for human use.
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Brief DescriptionCAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
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DescriptionCAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK|COX-2|NF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number469-83-0
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Formula Weight316.43
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Molecular FormulaC20H28O3
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Purity>98% (HPLC)
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SolubilityDMSO:5 mg/mL (15.8 mM)
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SMILES[H][C@]12CC[C@@]34C[C@@H](CC[C@@]3([H])[C@]1(C)CCc1occc21)[C@@](O)(CO)C4
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Chemical Name(3bS5aS7R8R10aR10bS)-7-(Hydroxymethyl)-10b-methyl-3b4567891010a10b1112-dodecahydro-5a8-methanocyclohepta[56]naphtho[21-b]furan-7-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shen T Lee J Lee E et al. Cafestol a Coffee-Specific Diterpene Is a Novel Extracellular Signal-Regulated Kinase Inhibitor with AP-1-Targeted Inhibition of Prostaglandin E2 Production in Lipopolysaccharide-Activated Macrophages[J]. Biological & Pharmaceutical Bulletin 2010 33(1):128-132.
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