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ERK-IN-4
CAS No. 1049738-54-6
ERK-IN-4( —— )
Catalog No. M34872 CAS No. 1049738-54-6
ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 101 | In Stock |
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| 2MG | 52 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 231 | In Stock |
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| 50MG | 334 | In Stock |
|
| 100MG | 499 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameERK-IN-4
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NoteResearch use only, not for human use.
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Brief DescriptionERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.
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DescriptionERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4has little effect on ERK protein phosphorylation by its upstream activator MEK1/2.
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In VitroCell Proliferation AssayCell Line:HeLa, A549, or SUM-159 cells Concentration:10 μM, 20 μM, 30 μM, 40 μM, 150 μM for A549, or SUM-159 cells; 25 μM, 50 μM, 75 μM for HeLa cells Incubation Time:10 days Result:Completely inhibited cell proliferation.
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK
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Research Area——
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Indication——
Chemical Information
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CAS Number1049738-54-6
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Formula Weight328.814
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Molecular FormulaC14H17ClN2O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (76.03 mM; Ultrasonic (<80°C)
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SMILESCl.O=C1SC(=CC2=CC=C(OCC)C=C2)C(=O)N1CCN
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95.?
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