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Home - Products - MAPK/ERK Signaling - ERK - ERK5-IN-5

ERK5-IN-5

CAS No. 2318792-30-0

ERK5-IN-5( —— )

Catalog No. M37092 CAS No. 2318792-30-0

ERK5-IN-5 is a potent extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity and potential anticonvulsant activity that inhibits A549 cell proliferation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ERK5-IN-5
  • Note
    Research use only, not for human use.
  • Brief Description
    ERK5-IN-5 is a potent extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity and potential anticonvulsant activity that inhibits A549 cell proliferation.
  • Description
    ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor with anticancer activity. ERK5-IN-5 exhibits good anti-proliferative activity with the IC50 value of 6.23 μg/mL for A549 cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    ERK
  • Recptor
    ERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2318792-30-0
  • Formula Weight
    337.8
  • Molecular Formula
    C19H16ClN3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (296.03 mM; Ultrasonic )
  • SMILES
    O=C(C1=CC=C(Cl)C=C1)N2CC=C(C3=CNC=4N=CC=CC43)CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Qin Zhang, et al. Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity. Bioorg Med Chem. 2023 Oct 14:95:117503. ?
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