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FR 180204
CAS No. 865362-74-9
FR 180204( FR180204 | FR-180204 )
Catalog No. M16283 CAS No. 865362-74-9
FR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 70 | In Stock |
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| 10MG | 126 | In Stock |
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| 25MG | 210 | In Stock |
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| 50MG | 314 | In Stock |
|
| 100MG | 471 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFR 180204
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NoteResearch use only, not for human use.
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Brief DescriptionFR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively.
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DescriptionFR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively; inhibits TGFβ-induced luciferase-expression in mink lung epithelial Mv1Lu cells, decreases plasma anti-CII antibody levels and attenuates delayed-type hypersensitivity in CII-immunized DBA/1 mice, also inhibits in vitro CII-induced proliferation of lymph node cells prepared from CII-immunized mice; enhances apoptotic and anti-proliferative effects of Akt inhibitor API-1 in human DLD-1 and LoVo colorectal cancer cells.
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In VitroIn AP-1-transfected cells, FR180204 dose-dependently inhibits AP-1 transactivation with IC50 of 3.1 μM.?FR 180204 inhibits spontaneous mesothelioma cell growth.
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In VivoFR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice.In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters.
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SynonymsFR180204 | FR-180204
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK1|ERK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number865362-74-9
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Formula Weight327.3427
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Molecular FormulaC18H13N7
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 50 mg/mL
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SMILESNC1=NNC2=NN=C(C3=C4C=CC=CN4N=C3C5=CC=CC=C5)C=C21
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Chemical Name1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ohori M, et al. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63.
2. Ohori M, et al. Naunyn Schmiedebergs Arch Pharmacol.
3. Chen-Roetling J, et al. Neuropharmacology. 2009 Apr;56(5):922-8.
4. Saglam AS, et al. Oncol Lett. 2016 Oct;12(4):2463-2474.
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