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BIX02189 (b)
CAS No. 1094614-85-3
BIX02189 (b)( —— )
Catalog No. M10368 CAS No. 1094614-85-3
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
|
| 5MG | 75 | In Stock |
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| 10MG | 119 | In Stock |
|
| 25MG | 221 | In Stock |
|
| 50MG | 369 | In Stock |
|
| 100MG | 569 | In Stock |
|
| 200MG | 806 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBIX02189 (b)
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NoteResearch use only, not for human use.
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Brief DescriptionBIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays.
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DescriptionBIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK5| MEK1| MEK2| MEK5| TGFβR1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1094614-85-3
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Formula Weight440.54
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Molecular FormulaC27H28N4O2
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Purity>98% (HPLC)
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SolubilityEthanol: 80 mg/mL (181.59 mM); DMSO: 60 mg/mL warmed (136.19 mM)
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SMILESCN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tatake RJ, et al. Biochem Biophys Res Commun, 2008, 377(1), 120-125.
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