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Home - Products - MAPK/ERK Signaling - ERK - SMI-4a

SMI-4a

CAS No. 327033-36-3

SMI-4a( SMI-4a )

Catalog No. M18425 CAS No. 327033-36-3

TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 63 In Stock
25MG 113 In Stock
50MG 203 In Stock
100MG 305 In Stock
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Biological Information

  • Product Name
    SMI-4a
  • Note
    Research use only, not for human use.
  • Brief Description
    TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
  • Description
    TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SMI-4a
  • Pathway
    MAPK/ERK Signaling
  • Target
    ERK
  • Recptor
    Pim 1| Pim 2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    327033-36-3
  • Formula Weight
    273.23
  • Molecular Formula
    C11H6F3NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL; 365.99 mM
  • SMILES
    c1cc(cc(c1)C(F)(F)F)/C=C/1\C(=O)NC(=O)S1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lin YW, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33.
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