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ASTX029
CAS No. 2095719-92-7
ASTX029( ASTX-029 )
Catalog No. M22011 CAS No. 2095719-92-7
ASTX029 is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 119 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 235 | In Stock |
|
| 50MG | 416 | In Stock |
|
| 100MG | 613 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameASTX029
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NoteResearch use only, not for human use.
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Brief DescriptionASTX029 is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.
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DescriptionASTX029 is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.
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In VitroWestern Blot Analysis Cell Line:A375 and HCT116 cells Concentration:1 nM-100 nM Incubation Time:2 h Result:Decreased pRSK and pERK.Apoptosis Analysis Cell Line:A375 and HCT116 cells Concentration:0-100 nM Incubation Time:0-72 h Result:Arrested cell in the G1-phase.Increased cleaved PARP and Bim protein level.
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In VivoAnimal Model:Colo205, A375, Calu-6, HCC44, HCT116 or MA-MEL-28 xenografts tumor-bearing mice Dosage:75 mg/kg Administration:p.o., once daily Result:Inhibited tumor growth in various tumor models.
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SynonymsASTX-029
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK1/2
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Research Area——
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Indication——
Chemical Information
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CAS Number2095719-92-7
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Formula Weight584.04
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Molecular FormulaC29H31ClFN5O5
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Purity>98% (HPLC)
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SolubilityDMSO：98 mg/mL (167.8 mM); Ethanol:48 mg/mL (82.2 mM)
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SMILESCOC1=CC(F)=CC(=C1)[C@@H](CO)NC(=O)[C@@H](C)N1CC2=CC=C(C=C2C1=O)C1=NC(NC2CCOCC2)=NC=C1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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