Longdaysin

CAS No. 1353867-91-0

Longdaysin( —— )

Catalog No. M20113 CAS No. 1353867-91-0

Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 45 In Stock
5MG 41 In Stock
10MG 67 In Stock
25MG 135 In Stock
50MG 211 In Stock
100MG 319 In Stock
200MG 458 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Longdaysin
  • Note
    Research use only, not for human use.
  • Brief Description
    Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).
  • Description
    Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).
  • In Vitro
    Western Blot Analysis Cell Line:HEK293T cells Concentration:0-50 μM Incubation Time:24 h Result:Reduced the levels of phosphorylated LRP6, total LRP6, phosphorylated DVL2, activated β-catenin, and total β-catenin.
  • In Vivo
    Animal Model:MDA-MB-231 xenografts Dosage:5 mg/kg Administration:i.p., every 3 days for 3 weeks Result:Decreased tumor cell density and proliferation (indicated by Ki-67).Reduced the expression of active and total β-catenin, and decreased the expression of phosphorylated and total LRP6, phosphorylated DVL2, and active and total β-catenin.Reduced mRNA expression of the Wnt target genes including Axin2, DKK1, LEF1, and Survivin.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Casein Kinase
  • Recptor
    CKIα| CKIδ|CDK7|ERK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1353867-91-0
  • Formula Weight
    335.33
  • Molecular Formula
    C16H16F3N5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mg/mL (298.21 mM);Water: Insoluble
  • SMILES
    CC(C)n1cnc2c(NCc3cccc(c3)C(F)(F)F)ncnc12
  • Chemical Name
    9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hirota T et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559.
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