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Longdaysin
CAS No. 1353867-91-0
Longdaysin( —— )
Catalog No. M20113 CAS No. 1353867-91-0
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
|
| 10MG | 105 | In Stock |
|
| 25MG | 213 | In Stock |
|
| 50MG | 340 | In Stock |
|
| 100MG | 515 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLongdaysin
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NoteResearch use only, not for human use.
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Brief DescriptionLongdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).
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DescriptionLongdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).
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In VitroWestern Blot Analysis Cell Line:HEK293T cells Concentration:0-50 μM Incubation Time:24 h Result:Reduced the levels of phosphorylated LRP6, total LRP6, phosphorylated DVL2, activated β-catenin, and total β-catenin.
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In VivoAnimal Model:MDA-MB-231 xenografts Dosage:5 mg/kg Administration:i.p., every 3 days for 3 weeks Result:Decreased tumor cell density and proliferation (indicated by Ki-67).Reduced the expression of active and total β-catenin, and decreased the expression of phosphorylated and total LRP6, phosphorylated DVL2, and active and total β-catenin.Reduced mRNA expression of the Wnt target genes including Axin2, DKK1, LEF1, and Survivin.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCKIα| CKIδ|CDK7|ERK2
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Research Area——
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Indication——
Chemical Information
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CAS Number1353867-91-0
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Formula Weight335.33
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Molecular FormulaC16H16F3N5
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL (298.21 mM);Water: Insoluble
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SMILESCC(C)n1cnc2c(NCc3cccc(c3)C(F)(F)F)ncnc12
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Chemical Name9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hirota T et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559.
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