ON108110( ON-108110 | ON 108110 )

Catalog No. M11727 CAS No. 1415599-79-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

ON108110
Note

Research use only, not for human use.
Brief Description

ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM).
Description

ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM); reduces replication of influenza A virus in a dose-dependent manner by suppressing viral RNA synthesis, also inhibits other viruses including vesicular stomatitis virus and Newcastle disease virus; inhibits MCL and T-ALL cell growth (GI50 values of 0.2-3 uM), inhibits CK2 and CDK4/6 mediated oncogenic signaling.
In Vitro

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In Vivo

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Synonyms

ON-108110 | ON 108110
Pathway

Metabolic Enzyme/Protease
Target

Casein Kinase
Recptor

Casein Kinase
Research Area

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Indication

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CAS Number

1415599-79-9
Formula Weight

374.342
Molecular Formula

C17H11FN2O5S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(Z)-4-((6-fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-ylidene)methyl)-2-nitrophenyl acetate

1. Padgaonkar A, et al. Oncotarget. 2018 Dec 28;9(102):37753-37765. 2. Martinez-Gil L, et al. Antiviral Res. 2013 Oct;100(1):29-37.

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